Andre Arendse made his debut in 1991 for Cape Town Spurs and later played professionally for Oxford United, Fulham, Santos, Mamelodi Sundowns and SuperSport United.
He represented South Africa 67 times having made his debut in 1995, was part of the squad that won the 1996 African Cup of Nations and was a participant at the 2002 FIFA World Cup. Andre retired from his international career in 2004.
He retired from football in 2009 winning the Premier Soccer League title with SuperSport United. In May 2013, Arendse returned as an emergency goalkeeper for Bidvest Wits. This made him the oldest player in PSL history surpassing the previous record set by Bruce Grobbelaar.
Since retiring from football Andre has been assistant and goalkeeper coach for Bidvest Wits, a co-presenter with SuperSport and is the current Supersport United Goalkeeper Coach.